Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 19/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147610 | 0.91 | RET (0.51) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20069109 | 0.86 | RET (0.47) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20069794 | 0.84 | RET (0.51) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20206019 | 0.81 | RET (0.48) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24441504 | 0.79 | RET (0.43) | RET | |
| SCHEMBL20147649 | 0.78 | RET (0.41) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20147612 | 0.77 | RET (0.45) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20147644 | 0.77 | RET (0.42) | RETPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20147620 | 0.76 | RET (0.46) | RET | |
| SCHEMBL20147642 | 0.76 | RET (0.45) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |