Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 3/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 1/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206018 | 0.89 | EGLN1 (0.46) | EGLN1NNMTGABRA5RETCD274 | |
| SCHEMBL20147605 | 0.87 | EGLN1 (0.45) | EGLN1NNMTGABRA5RETCD274 | |
| SCHEMBL20158548 | 0.85 | EGLN1 (0.44) | EGLN1NNMTGABRA5RETCD274 | |
| SCHEMBL20068964 | 0.83 | HDAC1 (0.51) | EGLN1GABRA5RETGABRA1 | |
| SCHEMBL20070360 | 0.76 | RET (0.46) | RETMCHR1 | |
| SCHEMBL20070353 | 0.75 | RET (0.42) | EGLN1RETMCHR1 | |
| SCHEMBL20069785 | 0.75 | TSHR (0.51) | — | |
| SCHEMBL20069783 | 0.75 | RET (0.44) | RETMCHR1 | |
| SCHEMBL20153163 | 0.75 | GPR183 (0.53) | NNMTGABRA5RETKCNH2GPR183 | |
| SCHEMBL20069112 | 0.74 | BDKRB1 (0.38) | CD274MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |