Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069779 | 0.90 | CYP3A4 (0.44) | RETALDH1A1SMN1; SMN2CYP3A4HPGD | |
| SCHEMBL20206025 | 0.85 | HRH3 (0.39) | RETALDH1A1SMN1; SMN2CYP3A4HPGD | |
| SCHEMBL20069154 | 0.84 | RET (0.41) | RETALDH1A1MAPK1NAMPTKMT2A | |
| SCHEMBL18377462 | 0.82 | CYP3A4 (0.42) | ALDH1A1SMN1; SMN2CYP3A4HPGDMAPK1 | |
| SCHEMBL20069676 | 0.78 | TSHR (0.52) | ALDH1A1SMN1; SMN2HPGDKDM4EMEN1 | |
| SCHEMBL22172283 | 0.76 | KMT2A (0.41) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL20148017 | 0.76 | SMN1; SMN2 (0.43) | RETALDH1A1SMN1; SMN2CYP3A4HPGD | |
| SCHEMBL20158498 | 0.74 | SMN1; SMN2 (0.43) | RETALDH1A1SMN1; SMN2CYP3A4HPGD | |
| SCHEMBL19198339 | 0.73 | EPHX1 (0.44) | ALDH1A1SMN1; SMN2CYP3A4HPGDNPC1 | |
| SCHEMBL20158595 | 0.72 | RET (0.41) | RETALDH1A1SMN1; SMN2CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |