Sugi Predict

Sugi Predict / Compounds / SCHEMBL20069720

SCHEMBL20069720

SCHEMBL20069720

CC(C)CC(=O)NC1CCN(C)CC1O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ TP53 P04637 1/20 0.39
▸ RET P07949 9/20 0.38
▸ KDM5A P29375 1/20 0.36
▸ SSTR1 P30872 1/20 0.35
▸ SSTR4 P31391 1/20 0.35
▸ PREP P48147 1/20 0.34
▸ CCNT1 O60563 1/20 0.33
▸ ULK1 O75385 1/20 0.33
▸ PRKD3 O94806 1/20 0.33
▸ PAK4 O96013 1/20 0.33
▸ CDK1 P06493 1/20 0.33
▸ CDK4 P11802 1/20 0.33
▸ CCNB1 P14635 1/20 0.33
▸ PHKG2 P15735 1/20 0.33
▸ ERCC2 P18074 1/20 0.33
▸ CCNA2 P20248 1/20 0.33
▸ CCND1 P24385 1/20 0.33
▸ CCNE1 P24864 1/20 0.33
▸ CDK2 P24941 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20070146 0.86 SMN1; SMN2 (0.38) SMN1; SMN2TP53RETKDM5A
SCHEMBL20070059 0.84 SMN1; SMN2 (0.38) SMN1; SMN2TP53RETKDM5ASSTR1
SCHEMBL20147509 0.84 RET (0.38) SMN1; SMN2TP53RETKDM5APREP
SCHEMBL25503417 0.84 RET (0.38) SMN1; SMN2TP53RETKDM5APREP
SCHEMBL18361599 0.83 SSTR1 (0.37) SSTR1SSTR4DRD2
SCHEMBL20147983 0.81 RET (0.37) SMN1; SMN2TP53RETKDM5APREP
SCHEMBL18347993 0.80 CHRNB4 (0.36) KDM5ASSTR1SSTR4PREPCTSK
SCHEMBL12932589 0.80 KDM5A (0.48) SMN1; SMN2TP53KDM5ASSTR1SSTR4
SCHEMBL20158581 0.79 RET (0.36) SMN1; SMN2TP53RETKDM5APREP
SCHEMBL15980408 0.77 OGA (0.38) SMN1; SMN2SSTR1SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-01-05 — — US disclosed
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2020-12-10 — — US disclosed
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2020-01-30 — — US disclosed
WO-2018071454-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ANDREWS STEVEN W (US) 2018-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200383966-A9 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 SMN1; SMN2 646/4885TP53 759/4885RET 1/4885
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 SMN1; SMN2 646/4885TP53 759/4885RET 1/4885
US-20200030311-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 SMN1; SMN2 646/4885TP53 759/4885RET 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.