Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154582 | 0.89 | RET (0.47) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL22030577 | 0.87 | RET (0.47) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL20069727 | 0.86 | RET (0.44) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL20153142 | 0.83 | RET (0.41) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL20160504 | 0.81 | RET (0.46) | RETALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL20069728 | 0.74 | RET (0.48) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL20152348 | 0.72 | RET (0.45) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL21158895 | 0.71 | RET (0.45) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL22030851 | 0.71 | RET (0.44) | RETDPP4DPP7ALDH1A1CYP1A2 | |
| SCHEMBL21159093 | 0.70 | CHRM1 (0.52) | ALDH1A1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071447-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |