Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12110130 | 0.86 | JAK2 (0.39) | JAK2JAK1JAK3RETSMN1; SMN2 | |
| SCHEMBL18390115 | 0.84 | RET (0.39) | JAK2JAK1JAK3RETDRD2 | |
| SCHEMBL20148018 | 0.83 | JAK2 (0.40) | JAK2JAK1JAK3RETSMN1; SMN2 | |
| SCHEMBL17071899 | 0.82 | DPP4 (0.38) | JAK2JAK1JAK3RETDRD2 | |
| SCHEMBL22857029 | 0.80 | JAK2 (0.39) | JAK2JAK1JAK3RETSMN1; SMN2 | |
| SCHEMBL22172283 | 0.79 | KMT2A (0.41) | DRD2DRD4 | |
| SCHEMBL20069677 | 0.75 | CYP2C19 (0.46) | RETDRD2DRD4SMN1; SMN2TRPA1 | |
| SCHEMBL20069769 | 0.73 | RET (0.36) | RETDRD2DRD4TRPA1MMP9 | |
| SCHEMBL20069779 | 0.73 | CYP3A4 (0.44) | RETSMN1; SMN2 | |
| SCHEMBL18390127 | 0.73 | RET (0.38) | RETHIF1AMMP9MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |