Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069291 | 0.83 | MEN1 (0.42) | LMNAALDH1A1ALOX15SMN1; SMN2POLB | |
| SCHEMBL20070610 | 0.80 | RET (0.44) | ALDH1A1SMN1; SMN2POLBL3MBTL1CHRM2 | |
| SCHEMBL20069293 | 0.76 | RET (0.49) | LMNAALDH1A1ALOX15POLBKDM4E | |
| SCHEMBL28664232 | 0.76 | SMN1; SMN2 (0.41) | ALDH1A1ALOX15SMN1; SMN2POLBKDM4E | |
| SCHEMBL20148104 | 0.75 | RET (0.48) | ALDH1A1ALOX15POLBKDM4ETSHR | |
| SCHEMBL20070066 | 0.75 | RET (0.47) | LMNATDP1ALDH1A1ALOX15POLB | |
| SCHEMBL20148111 | 0.75 | RET (0.47) | ALDH1A1ALOX15HDAC6HDAC1SMN1; SMN2 | |
| SCHEMBL20148110 | 0.74 | CYP3A4 (0.44) | ALDH1A1SMN1; SMN2POLBKDM4ECYP1A2 | |
| SCHEMBL28660592 | 0.74 | CYP1A2 (0.39) | ALDH1A1SMN1; SMN2POLBCYP1A2CYP3A4 | |
| SCHEMBL20069289 | 0.73 | RET (0.48) | LMNATDP1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |