Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2604735 | 0.76 | CYP3A4 (0.46) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL12733477 | 0.75 | CYP3A4 (0.44) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL20158532 | 0.74 | RET (0.49) | CYP3A4CYP2D6CNR2ALDH1A1PTGER4 | |
| SCHEMBL2604728 | 0.74 | CYP3A4 (0.43) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL15626080 | 0.73 | CYP3A4 (0.51) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL15745586 | 0.73 | CYP3A4 (0.51) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL14289638 | 0.73 | CYP3A4 (0.51) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL21651941 | 0.73 | RET (0.37) | CYP3A4CYP2D6 | |
| SCHEMBL172515 | 0.71 | CYP3A4 (0.53) | CYP3A4CYP2D6WNT1GSK3BDYRK1A | |
| SCHEMBL490080 | 0.71 | CYP3A4 (0.53) | CYP3A4CYP2D6WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |