Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 10/20 | 0.37 |
| ▸ | XIAP | P98170 | 8/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147494 | 0.90 | RET (0.47) | RETBIRC2XIAP | |
| SCHEMBL20147922 | 0.88 | RET (0.46) | RETBIRC2XIAP | |
| SCHEMBL20070138 | 0.84 | RET (0.44) | RETDRD2 | |
| SCHEMBL20070148 | 0.83 | RET (0.48) | RETDRD2 | |
| SCHEMBL21651960 | 0.80 | RET (0.41) | RETDRD2 | |
| SCHEMBL20158493 | 0.78 | RET (0.44) | RETDRD2 | |
| SCHEMBL20069523 | 0.77 | RET (0.44) | RET | |
| SCHEMBL20070147 | 0.75 | RET (0.43) | RETDRD2 | |
| SCHEMBL21651931 | 0.75 | RET (0.45) | RETDRD2 | |
| SCHEMBL20147498 | 0.74 | RET (0.47) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |