Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 15/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652004 | 0.85 | HCRTR1 (0.48) | HCRTR1HCRTR2CCR1CCR5CCR8 | |
| SCHEMBL20147435 | 0.85 | HRH3 (0.52) | HCRTR1HCRTR2CCR1CCR5CCR8 | |
| SCHEMBL21311492 | 0.82 | LOX (0.46) | PIK3CDLRRK2 | |
| SCHEMBL427767 | 0.82 | LRRK2 (0.48) | HCRTR1HCRTR2CCR1CCR5CCR8 | |
| SCHEMBL17448852 | 0.82 | HCRTR1 (0.49) | HCRTR1HCRTR2CCR1CCR5CCR8 | |
| SCHEMBL28664238 | 0.81 | ROCK1 (0.49) | HCRTR1HCRTR2CCR1CCR5CCR8 | |
| SCHEMBL21723114 | 0.81 | HCRTR1 (0.45) | HCRTR1HCRTR2PIK3CDLRRK2 | |
| SCHEMBL17308301 | 0.78 | LOX (0.52) | HCRTR1HCRTR2PIK3CDLRRK2 | |
| SCHEMBL18672932 | 0.78 | TLR9 (0.43) | LRRK2 | |
| SCHEMBL6898999 | 0.78 | GSK3B (0.44) | PIK3CDLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |