Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20147523 | 0.86 | RET (0.42) | RETKMT2AMEN1HRH3ALDH1A1 | |
| SCHEMBL20206053 | 0.84 | RET (0.41) | RETTDP1KMT2AMEN1HRH3 | |
| SCHEMBL20070364 | 0.79 | RET (0.41) | RETKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20069516 | 0.78 | RET (0.44) | RETKMT2ALMNAALDH1A1 | |
| SCHEMBL20069523 | 0.77 | RET (0.44) | RETTDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20070371 | 0.77 | RET (0.46) | RETTDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20070365 | 0.76 | RET (0.43) | RETKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL20069520 | 0.75 | RET (0.43) | RETKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20069721 | 0.75 | RET (0.42) | RETKMT2AMEN1HRH3SMN1; SMN2 | |
| SCHEMBL20069522 | 0.75 | RET (0.43) | RETKMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |