Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174846 | 0.82 | DPP4 (0.40) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4174724 | 0.77 | PIK3CD (0.52) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4175678 | 0.77 | DPP4 (0.40) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4174947 | 0.76 | DPP4 (0.44) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4179102 | 0.72 | DPP4 (0.40) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4169571 | 0.72 | MAPT (0.48) | DPP4KMT2APIK3CDGAAMGAM | |
| SCHEMBL19788621 | 0.71 | DPP4 (0.41) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4169580 | 0.71 | DPP4 (0.40) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL4178860 | 0.71 | DPP4 (0.44) | DPP4KDM4EALDH1A1GLAKMT2A | |
| SCHEMBL19788607 | 0.69 | DPP4 (0.39) | DPP4KMT2APIK3CDGAADPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105532-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105532-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | GRM2 2148/4885DPP4 4588/4885KDM4E 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.