Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 9/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19788596 | 0.84 | HPGD (0.39) | MEN1ALDH1A1KMT2AHSD17B10TSHR | |
| SCHEMBL4175806 | 0.83 | ADORA2A (0.40) | CYP3A4CYP2C9TACR3USP2CYP1A2 | |
| SCHEMBL4170998 | 0.75 | NT5E (0.44) | CYP3A4CYP2C9TACR3USP2CYP1A2 | |
| SCHEMBL4178011 | 0.73 | ADORA2A (0.47) | CYP3A4CYP2D6TACR3CYP1A2ALDH1A1 | |
| SCHEMBL12605690 | 0.72 | NPC1 (0.37) | CYP3A4CYP2C9CYP2D6CYP2C19MEN1 | |
| SCHEMBL20072535 | 0.71 | HPGD (0.40) | MEN1ALDH1A1KMT2AHSD17B10TSHR | |
| SCHEMBL12974145 | 0.71 | NT5E (0.38) | CYP3A4CYP2C9USP2CYP1A2CYP2C19 | |
| SCHEMBL21705933 | 0.70 | HPGD (0.37) | MEN1ALDH1A1KMT2AHSD17B10TSHR | |
| SCHEMBL19788597 | 0.70 | PIK3CD (0.36) | MEN1ALDH1A1KMT2AHSD17B10LMNA | |
| SCHEMBL21705350 | 0.70 | HPGD (0.48) | CYP3A4CYP2C9CYP2D6USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105532-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105532-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | CYP3A4 3267/4885CYP2C9 2845/4885CYP2D6 2966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.