Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20064055 | 0.88 | KMT2A (0.62) | POLBCYP1A2CYP2D6ALDH1A1KDM4E | |
| SCHEMBL14435528 | 0.87 | POLB (1.00) | POLBCYP2C19CYP1A2CYP2D6CD274 | |
| SCHEMBL4168121 | 0.83 | POLB (0.80) | POLBCYP2C19CYP1A2CYP2D6CD274 | |
| SCHEMBL19175419 | 0.83 | POLB (0.80) | POLBCYP2C19CYP1A2CYP2D6CD274 | |
| SCHEMBL11478379 | 0.83 | CD274 (0.71) | POLBCD274ALDH1A1HTR1AMAOA | |
| SCHEMBL12305581 | 0.81 | SMN1; SMN2 (0.64) | POLBCYP2D6CD274ALDH1A1HTR1A | |
| SCHEMBL10203243 | 0.80 | CYP2C19 (0.68) | POLBCYP2C19CYP1A2CYP2D6CD274 | |
| SCHEMBL280240 | 0.80 | MEN1 (0.76) | POLBCYP2C19CD274ALDH1A1HTR1A | |
| SCHEMBL20671965 | 0.78 | CD274 (0.68) | POLBCD274ALDH1A1HTR1AMAOA | |
| SCHEMBL279958 | 0.78 | CYP2C19 (0.72) | POLBCYP2C19CYP1A2CYP2D6CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE (CN) | 2019-07-30 | — | — | US | disclosed |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | BRANDEIS UNIVERSITY | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364247-B2 | Preparation and use of novel protein kinase inhibitors | MAP3K20, MAP3K19, MAP3K5 | POLB 2025/4885CYP2C19 4486/4885CYP1A2 4730/4885 |
| US-20180105528-A1 | PREPARATION AND USE OF NOVEL PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K19, MAP3K5 | POLB 2025/4885CYP2C19 4486/4885CYP1A2 4730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.