Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 12/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25758601 | 0.85 | MAP4K1 (0.58) | ABL1MAP4K1JAK2TYK2ACVRL1 | |
| SCHEMBL24394271 | 0.84 | ABL1 (0.64) | ABL1MAP4K1JAK2TYK2 | |
| SCHEMBL31264647 | 0.84 | MEN1 (0.42) | MEN1LMNAHPGDALOX15ALOX12 | |
| SCHEMBL30424808 | 0.84 | ABL1 (0.64) | ABL1MAP4K1JAK2TYK2 | |
| SCHEMBL22647518 | 0.83 | MAP4K1 (0.53) | LMNASMN1; SMN2ABL1MAP4K1JAK2 | |
| SCHEMBL20861414 | 0.81 | ABL1 (0.54) | MEN1LMNAHPGDALOX15ALOX12 | |
| SCHEMBL31250315 | 0.79 | ABL1 (0.57) | ABL1MAP4K1GSK3BJAK2TYK2 | |
| SCHEMBL31250286 | 0.79 | ABL1 (0.57) | ABL1MAP4K1GSK3BJAK2TYK2 | |
| SCHEMBL20073384 | 0.79 | MAP4K1 (0.52) | ABL1MAP4K1GSK3BJAK2TYK2 | |
| SCHEMBL26677550 | 0.79 | TYK2 (0.53) | ABL1MAP4K1GSK3BJAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848370-A2 | TYK2 INHIBITORS AND USES THEREOF | Nimbus Lakshmi, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| WO-2018071794-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-19 | — | — | WO | disclosed |