Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 5/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20071835 | 1.00 | NR1H2 (0.36) | NR1H2NR1H3HSD11B1ALDH1A1TDP1 | |
| SCHEMBL23838196 | 1.00 | NR1H2 (0.36) | NR1H2NR1H3HSD11B1ALDH1A1TDP1 | |
| SCHEMBL20071914 | 1.00 | NR1H2 (0.36) | NR1H2NR1H3HSD11B1ALDH1A1TDP1 | |
| SCHEMBL23838164 | 1.00 | NR1H2 (0.36) | NR1H2NR1H3HSD11B1ALDH1A1TDP1 | |
| SCHEMBL20071913 | 0.92 | NR1H2 (0.40) | NR1H2NR1H3TDP1GRM2 | |
| SCHEMBL23824826 | 0.92 | NR1H2 (0.40) | NR1H2NR1H3TDP1GRM2 | |
| SCHEMBL21644330 | 0.92 | NR1H2 (0.40) | NR1H2NR1H3TDP1GRM2 | |
| SCHEMBL20071909 | 0.89 | NR1H2 (0.35) | NR1H2NR1H3HSD11B1ALDH1A1TDP1 | |
| SCHEMBL20072157 | 0.84 | NR1H2 (0.41) | NR1H2NR1H3ALDH1A1 | |
| SCHEMBL20074068 | 0.84 | NR1H2 (0.41) | NR1H2NR1H3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071313-A1 | N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |