Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21721750 | 0.86 | KDM5B (0.49) | TSHRKDM5B | |
| SCHEMBL31676999 | 0.86 | KDM5B (0.49) | TSHRKDM5B | |
| SCHEMBL20074110 | 0.86 | KDM5B (0.48) | TSHRTDP1KDM5BLMNAPKM | |
| SCHEMBL20074113 | 0.85 | KDM5B (0.44) | TSHRTDP1KDM5B | |
| SCHEMBL20074172 | 0.85 | KDM5B (0.41) | TSHRPIK3CDTDP1KDM5BLMNA | |
| SCHEMBL20074277 | 0.85 | KDM5B (0.42) | TSHRTDP1KDM5BLMNAPKM | |
| SCHEMBL21681717 | 0.84 | KDM5B (0.50) | TSHRBRD4KDM5B | |
| SCHEMBL21721688 | 0.84 | KDM5B (0.52) | TSHRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21681725 | 0.83 | KDM5B (0.51) | TSHRPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL31676980 | 0.83 | KDM5B (0.51) | TSHRPIK3CDPIK3CAPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071283-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | WO | disclosed |