Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.59 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.59 |
| ▸ | MTTP | P55157 | 9/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | MTR | Q99707 | 1/20 | 0.57 |
| ▸ | APOB | P04114 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23418516 | 0.86 | MTTP (0.65) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL3731129 | 0.84 | MTTP (0.59) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL3797899 | 0.84 | GAA (0.53) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL13351375 | 0.84 | MTTP (0.58) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL3731091 | 0.84 | DRD4 (0.68) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL593798 | 0.83 | GAA (0.56) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Hydrochloric Acid SCHEMBL17729930 | 0.82 | GAA (0.55) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL3730705 | 0.82 | GAA (0.59) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL3726145 | 0.82 | MTTP (0.54) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Bicarbonate SCHEMBL6218155 | 0.81 | MTTP (0.60) | MTTPCHRM2ADRA2AADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | LIPA, LPAR4, CETP | CHRNB2 2626/4885CHRNB4 2226/4885CHRNA3 3169/4885 |
| US-10023526-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | CHRNB2 2626/4885CHRNB4 2226/4885CHRNA3 3169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.