Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24114804 | 0.96 | TLR8 (0.42) | TLR8SMPD1MAPK14 | |
| SCHEMBL20074676 | 0.80 | MAPK14 (0.56) | TLR8MAPK14 | |
| SCHEMBL20074866 | 0.77 | SLC34A1 (0.47) | MAPK14 | |
| SCHEMBL20074996 | 0.77 | SLC34A1 (0.54) | MAPK14 | |
| SCHEMBL20074815 | 0.76 | SLC34A1 (0.56) | — | |
| SCHEMBL20075110 | 0.75 | SLC34A1 (0.52) | MAPK14 | |
| SCHEMBL21711509 | 0.75 | SLC34A1 (0.54) | MAPK14 | |
| SCHEMBL20075002 | 0.72 | SLC9A5 (0.34) | MAPK14 | |
| SCHEMBL20075127 | 0.71 | SLC34A1 (0.49) | MAPK14 | |
| SCHEMBL24114836 | 0.71 | MAPK14 (0.38) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |