Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | GRM5 | P41594 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20075564 | 0.82 | GRM5 (0.47) | MAPK14GRM5LMNASMN1; SMN2 | |
| SCHEMBL20075418 | 0.81 | MAPK14 (0.44) | MAPK14GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL25435704 | 0.79 | MAPK14 (0.43) | MAPK14GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL20550958 | 0.79 | KMT2A (0.43) | MAPK14GRM5LMNA | |
| SCHEMBL20074942 | 0.78 | SLC34A1 (0.45) | MAPK14GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL20075536 | 0.78 | SLC34A1 (0.46) | MAPK14 | |
| SCHEMBL20075467 | 0.78 | NSD2 (0.45) | HTT | |
| SCHEMBL20075477 | 0.77 | MAPK14 (0.59) | MAPK14KDM4EALDH1A1LMNAHTT | |
| SCHEMBL21711412 | 0.77 | MAPK14 (0.41) | MAPK14GRM5KDM4EALDH1A1LMNA | |
| SCHEMBL20075377 | 0.77 | ADORA2A (0.47) | MAPK14KDM4EALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |