Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20074615 | 0.81 | MAPK14 (0.53) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL20075097 | 0.81 | SLC34A1 (0.47) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL21711385 | 0.71 | IKBKB (0.58) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL20075417 | 0.71 | MAPK1 (0.69) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL2523390 | 0.69 | MAPK14 (0.40) | MAPK14MAPK1 | |
| SCHEMBL6132067 | 0.68 | MAPK1 (0.80) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL20074664 | 0.68 | MAPK14 (0.53) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL6132080 | 0.68 | MAPK1 (0.80) | MAPK14ABL1RPS6KA3KDRALK | |
| SCHEMBL7617137 | 0.68 | MAPK14 (0.59) | MAPK14MAPK9MAPK13MAPK12MAPK11 | |
| SCHEMBL6076585 | 0.67 | MAPK14 (1.00) | MAPK14RPS6KA3MAPK1NPSR1ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |