Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 3/20 | 0.46 |
| ▸ | AR | P10275 | 5/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046645 | 1.00 | CRBN (0.46) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL20046644 | 0.90 | CRBN (0.51) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL24734963 | 0.88 | CRBN (0.58) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL29494178 | 0.88 | CRBN (0.58) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL29841399 | 0.88 | CRBN (0.58) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL22645400 | 0.83 | CRBN (0.54) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL29841424 | 0.79 | CRBN (0.54) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL24734969 | 0.79 | CRBN (0.54) | CRBNHPGDSBTKARDDB1 | |
| SCHEMBL20046323 | 0.79 | AR (0.78) | CRBNHPGDSBTKAR | |
| SCHEMBL31427056 | 0.79 | AR (0.78) | CRBNHPGDSBTKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |