Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.54 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31604725 | 0.76 | HRH3 (0.45) | HRH3ALDH1A1CYP2A6CA1CA2 | |
| SCHEMBL5024491 | 0.76 | HRH3 (0.71) | HRH3FPR2PROKR1GPR119TRPC6 | |
| SCHEMBL22138868 | 0.76 | HRH3 (0.71) | HRH3FPR2PROKR1GPR119TRPC6 | |
| SCHEMBL4237757 | 0.76 | HRH3 (0.53) | HRH3FPR2PROKR1GPR119MMP13 | |
| Hydrochloric Acid SCHEMBL31604770 | 0.75 | HRH3 (0.44) | HRH3ALDH1A1CYP2A6CA1CA2 | |
| SCHEMBL4234096 | 0.75 | HRH3 (0.59) | HRH3FPR2PROKR1GPR119HRH2 | |
| SCHEMBL21130985 | 0.73 | HRH3 (0.67) | HRH3FPR2PROKR1GPR119TRPC6 | |
| SCHEMBL247758 | 0.73 | HRH3 (0.71) | HRH3FPR2PROKR1GPR119TRPC6 | |
| SCHEMBL5527463 | 0.73 | HRH3 (0.52) | HRH3FPR2PROKR1GPR119MMP13 | |
| SCHEMBL20205990 | 0.73 | HRH3 (0.71) | HRH3FPR2PROKR1GPR119TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |