Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27432720 | 0.87 | CACNA2D1 (0.48) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL20873836 | 0.86 | CNR1 (0.51) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL1100404 | 0.86 | CNR1 (0.51) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL27308696 | 0.85 | CACNA2D1 (0.47) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL19853552 | 0.85 | CNR1 (0.41) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL20873854 | 0.84 | HPGD (0.51) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL25338213 | 0.84 | NR1H2 (0.49) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL6152170 | 0.84 | HPGD (0.48) | NR1H2CNR1USP2SMN1; SMN2HPGD | |
| SCHEMBL2732005 | 0.83 | HPGD (0.50) | NR1H2CNR1USP2SMN1; SMN2CHRM2 | |
| SCHEMBL1307642 | 0.83 | EPHX1 (0.51) | NR1H2CNR1USP2SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |