Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.52 |
| ▸ | AR | P10275 | 6/20 | 0.52 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22661477 | 0.95 | CRBN (0.53) | CRBNARHPGDSBTKEGFR | |
| SCHEMBL23129212 | 0.93 | CRBN (0.60) | CRBNARHPGDSBTKEGFR | |
| SCHEMBL25901322 | 0.91 | CRBN (0.59) | CRBNARHPGDSBTKDDB1 | |
| SCHEMBL23129200 | 0.88 | CRBN (0.59) | CRBNARHPGDSDDB1EGFR | |
| SCHEMBL22661513 | 0.86 | CRBN (0.52) | CRBNARHPGDSBTKEGFR | |
| SCHEMBL22661378 | 0.86 | CRBN (0.50) | CRBNARHPGDSBTKDDB1 | |
| SCHEMBL22661374 | 0.86 | CRBN (0.50) | CRBNARHPGDSBTKDDB1 | |
| SCHEMBL23129271 | 0.86 | CRBN (0.52) | CRBNARHPGDSDDB1RAF1 | |
| SCHEMBL23128889 | 0.86 | CRBN (0.60) | CRBNARHPGDSDDB1RAF1 | |
| SCHEMBL23129276 | 0.85 | CRBN (0.60) | CRBNARHPGDSBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3660004-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| WO-2018071606-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. (US) | 2018-04-19 | — | — | WO | disclosed |