SCHEMBL20077397

SCHEMBL20077397

NC(CCC(=O)NC(C[S+]([O-])CC(=O)N1CCC1)C(=O)NCC(=O)O)C(=O)N=O

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.43
GSTK1 Q9Y2Q3 1/20 0.43
GLO1 Q04760 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22015955 0.76 PTGS1 (0.49) PTGS1GSTK1GLO1
SCHEMBL22015913 0.71 PTGS1 (0.64) PTGS1GSTK1GLO1
SCHEMBL22015926 0.71 PTGS1 (0.64) PTGS1GSTK1GLO1
SCHEMBL20077213 0.69 PTGS1 (0.67) PTGS1GSTK1GLO1
SCHEMBL20077231 0.69 PTGS1 (0.67) PTGS1GSTK1GLO1
SCHEMBL11870652 0.69 PTGS1 (0.57) PTGS1GSTK1GLO1
SCHEMBL11870629 0.69 PTGS1 (0.57) PTGS1GSTK1GLO1
SCHEMBL22015828 0.67 PTGS1 (0.64) PTGS1GSTK1GLO1
SCHEMBL22015660 0.67 PTGS1 (0.64) PTGS1GSTK1GLO1
SCHEMBL4677204 0.66 PTGS1 (0.56) PTGS1GSTK1GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018071741-A1 SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN MEDICINE EPICENTRIX, INC. (US) 2018-04-19 WO disclosed