Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 10/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248589 | 0.91 | DYRK1A (0.54) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2245973 | 0.90 | DYRK1A (0.53) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2248925 | 0.89 | SMN1; SMN2 (0.54) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2245427 | 0.88 | DYRK1A (0.47) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2245920 | 0.87 | DYRK1A (0.49) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL21066946 | 0.87 | DYRK1A (0.49) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2246691 | 0.87 | DYRK1A (0.49) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL2252658 | 0.86 | DYRK1A (0.45) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 | |
| SCHEMBL20080823 | 0.86 | DYRK1A (0.55) | DYRK1ACSNK1DACP1KDM4ENPC1 | |
| SCHEMBL2250749 | 0.85 | DYRK1A (0.44) | DYRK1ACSNK1DLRRK2CYP2D6ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536285-B1 | SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | VTV THERAPEUTICS LLC (US) | 2018-04-25 | — | — | EP | disclosed |