Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 11/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30158717 | 0.88 | FGFR4 (0.53) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16654547 | 0.83 | FGFR4 (0.59) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL23889762 | 0.80 | FGFR1 (0.67) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL28616991 | 0.77 | FGFR4 (0.53) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL2011577 | 0.76 | FGFR3 (0.74) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18131081 | 0.76 | FGFR4 (0.54) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16654074 | 0.74 | FGFR1 (0.75) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL22171984 | 0.74 | FGFR4 (0.83) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16654072 | 0.74 | FGFR1 (0.70) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL18398035 | 0.73 | FGFR4 (0.44) | FGFR4FGFR1FGFR3CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-B1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2018-04-25 | — | — | EP | disclosed |