Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20085248 | 0.86 | MEN1 (0.48) | GCKRXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18330558 | 0.84 | GCK (0.41) | GCKRXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31221536 | 0.84 | GCK (0.41) | GCKRXRBNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31221545 | 0.83 | GCK (0.40) | GCKRXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20084951 | 0.81 | GCK (0.39) | GCKRXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20084783 | 0.81 | GCK (0.46) | GCKRXRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL21971949 | 0.80 | GCK (0.38) | GCKNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18332197 | 0.80 | GCK (0.45) | GCKRXRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL18331768 | 0.80 | MEN1 (0.42) | GCKSMN1; SMN2MEN1KMT2A | |
| SCHEMBL20084824 | 0.79 | GCK (0.37) | GCKRXRBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |