Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LARS1 | Q9P2J5 | 3/20 | 0.36 |
| ▸ | CIT | O14578 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15843982 | 0.95 | SCN9A (0.58) | SCN9ACACNA1BPSEN1PSEN2APH1B | |
| SCHEMBL15843983 | 0.95 | SCN9A (0.58) | SCN9ACACNA1BPSEN1PSEN2APH1B | |
| SCHEMBL20088469 | 0.85 | SCN9A (0.49) | SCN9ACACNA1BPSEN1PSEN2APH1B | |
| SCHEMBL20088468 | 0.83 | CYP3A4 (0.42) | SCN9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20088467 | 0.82 | SCN9A (0.40) | SCN9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15844454 | 0.80 | SCN9A (0.52) | SCN9ACACNA1BMAPTALDH1A1 | |
| SCHEMBL15844455 | 0.80 | SCN9A (0.52) | SCN9ACACNA1BMAPTALDH1A1 | |
| SCHEMBL20088466 | 0.79 | SCN9A (0.37) | SCN9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20088440 | 0.79 | SCN9A (0.50) | SCN9A | |
| SCHEMBL3277765 | 0.77 | SCN9A (0.60) | SCN9ACITMAPTALDH1A1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111894-A1 | Benzimidazole Inhibitors of the Sodium Channel | DeGiacomo, Mark G. (US) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111894-A1 | Benzimidazole Inhibitors of the Sodium Channel | SCN1A, KCNJ11, KCNJ1 | SCN9A 52/4885CACNA1B 25/4885PSEN1 2105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.