Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.51 |
| ▸ | GSK3B | P49841 | 9/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.43 |
| ▸ | WNT1 | P04628 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20155856 | 0.89 | TYK2 (0.65) | TYK2GSK3BDYRK1AWNT1 | |
| SCHEMBL20093004 | 0.80 | TYK2 (0.48) | TYK2 | |
| SCHEMBL20156093 | 0.79 | TYK2 (0.68) | TYK2 | |
| SCHEMBL20156159 | 0.79 | TYK2 (0.68) | TYK2 | |
| SCHEMBL20155831 | 0.74 | TYK2 (0.64) | TYK2 | |
| SCHEMBL20092428 | 0.74 | TYK2 (0.49) | TYK2 | |
| SCHEMBL20155784 | 0.74 | TYK2 (0.67) | TYK2 | |
| SCHEMBL20093178 | 0.73 | TYK2 (0.41) | TYK2 | |
| SCHEMBL20092094 | 0.73 | TYK2 (0.62) | TYK2 | |
| SCHEMBL20092204 | 0.73 | TYK2 (0.60) | TYK2GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075937-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-26 | — | — | WO | disclosed |