Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 5/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20155861 | 0.88 | TYK2 (0.56) | TYK2 | |
| SCHEMBL20093029 | 0.88 | TYK2 (0.41) | TYK2CD274 | |
| SCHEMBL20093026 | 0.79 | TYK2 (0.49) | TYK2 | |
| SCHEMBL20093037 | 0.78 | TYK2 (0.60) | TYK2 | |
| SCHEMBL20093176 | 0.77 | TYK2 (0.44) | TYK2CD274 | |
| SCHEMBL20091777 | 0.76 | TYK2 (0.60) | TYK2 | |
| SCHEMBL20092064 | 0.75 | TYK2 (0.49) | TYK2 | |
| SCHEMBL20091770 | 0.75 | TYK2 (0.45) | TYK2 | |
| SCHEMBL20155835 | 0.75 | TYK2 (0.48) | TYK2 | |
| SCHEMBL20092311 | 0.75 | TYK2 (0.32) | TYK2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075937-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-26 | — | — | WO | disclosed |