SCHEMBL20093136

SCHEMBL20093136

CN(c1cc(-c2cncn2C)ccc1Nc1cc(NC(=O)C2C[C@@H]2F)nc2c1nc(C(F)F)n2C1CCCCO1)S(C)(=O)=O

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 20/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20092193 1.00 TYK2 (0.64) TYK2
SCHEMBL20092194 1.00 TYK2 (0.64) TYK2
SCHEMBL20156158 1.00 TYK2 (0.64) TYK2
SCHEMBL20092785 0.94 TYK2 (0.59) TYK2
SCHEMBL20093044 0.92 TYK2 (0.64) TYK2
SCHEMBL20156145 0.92 TYK2 (0.64) TYK2
SCHEMBL20092332 0.91 TYK2 (0.64) TYK2
SCHEMBL20093022 0.90 TYK2 (0.62) TYK2
SCHEMBL20092129 0.90 TYK2 (0.62) TYK2
SCHEMBL20092774 0.90 TYK2 (0.62) TYK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018075937-A1 TYK2 INHIBITORS AND USES THEREOF NIMBUS LAKSHMI, INC. (US) 2018-04-26 WO disclosed