Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.52 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 4/20 | 0.49 |
| ▸ | BRD2 | P25440 | 4/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20093686 | 0.97 | RXFP1 (0.59) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL18174277 | 0.92 | TP53 (0.51) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL20093936 | 0.91 | TP53 (0.50) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL20094329 | 0.90 | TP53 (0.49) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL29741421 | 0.90 | TP53 (0.49) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL20093719 | 0.90 | TP53 (0.49) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL22133826 | 0.90 | TP53 (0.49) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL18174304 | 0.89 | TP53 (0.48) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL29741358 | 0.89 | TP53 (0.48) | TP53POLBRXFP1MAPTHCAR3 | |
| SCHEMBL22134066 | 0.88 | TP53 (0.52) | TP53POLBRXFP1MAPTHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3529248-B1 | PHARMACEUTICAL COMPOUNDS | CELLCENTRIC LTD (GB) | 2020-08-19 | — | — | EP | disclosed |
| WO-2018073586-A1 | PHARMACEUTICAL COMPOUNDS | CELLCENTRIC LTD (GB) | 2018-04-26 | — | — | WO | disclosed |