Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 3/20 | 0.33 |
| ▸ | NPY1R | P25929 | 2/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16627709 | 0.88 | SPHK1 (0.43) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16572314 | 0.88 | SPHK1 (0.43) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL19820039 | 0.83 | SPHK1 (0.45) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16572313 | 0.79 | SPHK1 (0.55) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16627708 | 0.74 | SPHK1 (0.52) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16627666 | 0.74 | SPHK1 (0.52) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL19820059 | 0.73 | SPHK1 (0.50) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16572292 | 0.73 | SPHK1 (0.53) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL16572312 | 0.73 | SPHK1 (0.53) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL18412680 | 0.66 | SPHK1 (0.54) | SPHK1SPHK2S1PR1S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111907-A1 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | PARION SCIENCES, INC. | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111907-A1 | DENDRIMER LIKE AMINO AMIDES POSSESSING SODIUM CHANNEL BLOCKER ACTIVITY FOR THE TREATMENT OF DRY EYE AND OTHER MUCOSAL DISEASES | SCNN1B, SCNN1A, SCNN1G | SPHK1 339/4885SPHK2 337/4885S1PR1 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.