Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634090 | 0.92 | HTR2A (0.38) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL19634093 | 0.84 | MEN1 (0.36) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL19001206 | 0.84 | MEN1 (0.36) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL20256208 | 0.84 | MEN1 (0.37) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL20256546 | 0.84 | KDM4E (0.36) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL20095558 | 0.83 | GAA (0.41) | SLC6A4MEN1KMT2ASCN1ASCN2A | |
| SCHEMBL20256130 | 0.83 | CYP1A2 (0.37) | MEN1KMT2ASCN1AKDM4ETSHR | |
| SCHEMBL20256424 | 0.83 | SCN1A (0.36) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL20256699 | 0.83 | KDM4E (0.38) | HTR2ASLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL20256524 | 0.83 | KDM4E (0.36) | MEN1KMT2ASCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |
| US-9242974-B2 | Processes for the preparation of 2-fluoro 6-11 bicyclic erythromycin derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2016-01-26 | — | — | US | disclosed |