Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34475148 | 0.95 | EPHX1 (0.54) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL19701814 | 0.92 | EPHX1 (0.49) | EPHX1L3MBTL1HPGDNR1H2ALDH1A1 | |
| SCHEMBL28779713 | 0.89 | EPHX1 (0.59) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL13434273 | 0.89 | EPHX1 (0.59) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL29042873 | 0.89 | EPHX1 (0.68) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL29012216 | 0.89 | EPHX1 (0.59) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL29042871 | 0.89 | EPHX1 (0.68) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL13696785 | 0.89 | EPHX1 (0.68) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL28779710 | 0.89 | EPHX1 (0.59) | EPHX1L3MBTL1THRBATMHPGD | |
| SCHEMBL5666472 | 0.88 | EPHX1 (0.57) | EPHX1L3MBTL1THRBATMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |