Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 10/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009590 | 0.85 | IDO1 (0.52) | CYP2C9MEN1KMT2AJAK2IDO1 | |
| SCHEMBL13834484 | 0.85 | IDO1 (0.52) | CYP2C9MEN1KMT2AJAK2IDO1 | |
| SCHEMBL12075943 | 0.84 | MAPT (0.45) | GRIN2BJAK2JAK1HTTGAA | |
| SCHEMBL13834569 | 0.83 | MEN1 (0.45) | CYP2D6CYP2C9CYP3A4MEN1KMT2A | |
| SCHEMBL2014265 | 0.83 | MEN1 (0.45) | CYP2D6CYP2C9CYP3A4MEN1KMT2A | |
| SCHEMBL12076105 | 0.82 | MAPT (0.43) | GRIN2BCYP2C9JAK2JAK1HTT | |
| SCHEMBL4718908 | 0.79 | KDM4E (0.48) | GRIN2BCYP2D6CYP2C9CYP3A4IDO1 | |
| SCHEMBL927695 | 0.74 | MEN1 (0.58) | MEN1KMT2AHTTGAAALDH1A1 | |
| SCHEMBL4140026 | 0.73 | MAPT (0.59) | MEN1KMT2AHTTGAAALDH1A1 | |
| SCHEMBL5758851 | 0.72 | MEN1 (0.48) | MEN1KMT2AHTTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503890-A1 | AZABENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011066211-A1 | AZABENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-06-03 | — | — | WO | disclosed |