Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095838 | 1.00 | SCN9A (0.48) | SCN9AHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL20063390 | 0.90 | SCN9A (0.51) | SCN9AHTR2C | |
| SCHEMBL20063410 | 0.88 | SCN9A (0.49) | SCN9AHTR2C | |
| SCHEMBL20063409 | 0.88 | SCN9A (0.49) | SCN9AHTR2C | |
| SCHEMBL20063450 | 0.88 | SCN9A (0.49) | SCN9AHTR2C | |
| SCHEMBL20063372 | 0.88 | SCN9A (0.49) | SCN9AHTR2C | |
| SCHEMBL23140857 | 0.82 | HTR2C (0.49) | SCN9AHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL31495941 | 0.82 | HTR2C (0.49) | SCN9AHTR2CDRD2HTR2AHTR2B | |
| SCHEMBL20063476 | 0.81 | SCN9A (0.51) | SCN9AHTR2C | |
| SCHEMBL23638938 | 0.80 | SCN9A (0.49) | SCN9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |