Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 6/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311688 | 1.00 | HTR2C (0.55) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL21311601 | 1.00 | HTR2C (0.55) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL29992351 | 0.85 | HTR2C (0.58) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL2532290 | 0.85 | HTR2C (0.72) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL16457233 | 0.82 | HTR2C (0.72) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL431853 | 0.81 | HTR2C (0.50) | HTR2CKDM1AMAOAMAOB | |
| SCHEMBL15336102 | 0.81 | HTR2C (0.66) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL20096265 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL20095708 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BDRD2KDM1A | |
| SCHEMBL20095961 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BDRD2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |