Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095865 | 1.00 | KMT2A (0.43) | KMT2AMEN1TP53HRH4HRH3 | |
| SCHEMBL20095863 | 1.00 | KMT2A (0.43) | KMT2AMEN1TP53HRH4HRH3 | |
| SCHEMBL19227260 | 0.81 | KMT2A (0.54) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL19227247 | 0.81 | KMT2A (0.54) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL19227269 | 0.81 | KMT2A (0.54) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL14876763 | 0.79 | KMT2A (0.45) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL16822343 | 0.79 | KMT2A (0.45) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL11068078 | 0.79 | KMT2A (0.45) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL17743412 | 0.79 | KMT2A (0.45) | KMT2AMEN1HRH4HRH3MAPT | |
| SCHEMBL19159040 | 0.79 | KMT2A (0.51) | KMT2AMEN1HRH4HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |