SCHEMBL20096420

SCHEMBL20096420

Cn1c(Nc2cccc(C(=O)NO)c2)nc2cc(C(F)(F)F)c(C#N)cc21

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HDAC11 Q96DB2 6/20 0.64
▸ HDAC6 Q9UBN7 11/20 0.53
▸ SCN9A Q15858 1/20 0.43
▸ HDAC7 Q8WUI4 2/20 0.41
▸ HDAC4 P56524 1/20 0.41
▸ HDAC9 Q9UKV0 1/20 0.41
▸ HDAC5 Q9UQL6 1/20 0.41
▸ BRAF P15056 3/20 0.41
▸ RAF1 P04049 2/20 0.41
▸ HDAC3 O15379 1/20 0.38
▸ HDAC1 Q13547 1/20 0.38
▸ HDAC2 Q92769 1/20 0.38
▸ HDAC8 Q9BY41 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20096579 0.96 HDAC11 (0.67) HDAC11HDAC6SCN9AHDAC7HDAC4
SCHEMBL29624663 0.96 HDAC11 (0.67) HDAC11HDAC6SCN9AHDAC7HDAC4
SCHEMBL20096684 0.91 HDAC11 (0.53) HDAC11HDAC6SCN9AHDAC7HDAC4
SCHEMBL20132892 0.90 HDAC11 (0.52) HDAC11HDAC6SCN9ABRAFRAF1
SCHEMBL20096421 0.89 HDAC11 (0.51) HDAC11HDAC6SCN9ABRAFRAF1
SCHEMBL20096428 0.88 HDAC11 (0.51) HDAC11HDAC6SCN9A
SCHEMBL20096645 0.87 HDAC6 (0.56) HDAC11HDAC6HDAC7HDAC4HDAC9
SCHEMBL29624706 0.87 HDAC11 (0.56) HDAC11HDAC6SCN9AHDAC7HDAC4
SCHEMBL20096429 0.87 HDAC11 (0.56) HDAC11HDAC6SCN9AHDAC7HDAC4
SCHEMBL29754097 0.85 HDAC11 (0.53) HDAC11HDAC6SCN9ABRAFRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479807-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2025-11-25 — — US disclosed
US-11345672-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2022-05-31 — — US disclosed
US-11345672-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2022-05-31 — — US disclosed
US-20200079744-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2020-03-12 — — US disclosed
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2019-03-21 — — US disclosed
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2019-03-21 — — US disclosed
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2019-03-21 — — US disclosed
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2019-03-21 — — US disclosed
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS VALO EARLY DISCOVERY, INC. 2018-05-10 — — US disclosed
WO-2018075959-A1 METHODS USING HDAC11 INHIBITORS FORMA THERAPEUTICS, INC. (US) 2018-04-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200079744-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885
US-11345672-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885
US-12479807-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HDAC11 1/4885HDAC6 6/4885SCN9A 3846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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