⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6606324 | 0.98 | — | — | |
| SCHEMBL6691379 | 0.84 | — | — | |
| SCHEMBL8145989 | 0.75 | — | — | |
| SCHEMBL8145993 | 0.75 | — | — | |
| SCHEMBL6752265 | 0.73 | CYP2D6 (0.44) | — | |
| SCHEMBL4357889 | 0.70 | — | — | |
| SCHEMBL13598576 | 0.70 | — | — | |
| SCHEMBL8298016 | 0.70 | — | — | |
| SCHEMBL13181713 | 0.70 | — | — | |
| SCHEMBL20207147 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104003922-A | Substituted pyrrolidine derivative, preparation method thereof and use in medicine | UNIV CHINA PHARMA | 2014-08-27 | — | — | CN | claimed |
| EP-1931633-A2 | DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2008-06-18 | — | — | EP | claimed |
| WO-2007029086-A2 | DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | claimed |
| US-20060293297-A1 | Cyanofluoropyrrolidine derviative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2006-12-28 | — | — | US | claimed |
| EP-1627870-A1 | CYANOFLUOROPYRROLIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-02-22 | — | — | EP | claimed |
| EP-1406873-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-14 | — | — | EP | claimed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | claimed |
| CN-114867719-A | Pyrrolidine and piperidine compounds | 柳韩洋行 | 2022-08-05 | — | — | CN | disclosed |
| CN-110075098-A | Purposes of the Li Gelieting in heart and protection renal antidiabetic treatment | 勃林格殷格翰国际有限公司 | 2019-08-02 | — | — | CN | disclosed |
| CN-104109111-B | The preparation method of Tosi acid Bei Gelieting and its intermediate | 江苏豪森药业集团有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-104926706-B | Salt of hexahydro pentalene derivative and its preparation method and application | 广东东阳光药业有限公司 | 2017-12-05 | — | — | CN | disclosed |
| US-9416105-B2 | Process for preparation of saxagliptin and its hydrochloride salt | AMNEAL PHARMACEUTICALS LLC (US) | 2016-08-16 | — | — | US | disclosed |
| US-20160194282-A1 | A Process For Preparation Of Saxagliptin And Its Hydrochloride Salt | AMNEAL PHARMACEUTICALS LLC | 2016-07-07 | — | — | US | disclosed |
| EP-1627870-A1 | CYANOFLUOROPYRROLIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-02-22 | — | — | EP | disclosed |
| JP-2005272457-A | PHARMACEUTICAL CONTAINING CYANOPYRROLIDINE DERIVATIVE AS ACTIVE INGREDIENT | TAISHO PHARMACEUT CO LTD | 2005-10-06 | — | — | JP | disclosed |
| WO-2004101514-A1 | CYANOFLUOROPYRROLIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2004-11-25 | — | — | WO | disclosed |
| EP-1406873-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-14 | — | — | EP | disclosed |
| EP-1399433-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |
| WO-2003002553-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |