Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.40 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | PRKCG | P05129 | 2/20 | 0.40 |
| ▸ | PRKCB | P05771 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 2/20 | 0.40 |
| ▸ | PRKCI | P41743 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2288241 | 0.91 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL1473437 | 0.90 | S1PR1 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2012128 | 0.87 | S1PR1 (0.45) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL13645061 | 0.86 | S1PR1 (0.52) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2008551 | 0.81 | S1PR1 (0.46) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2012129 | 0.79 | S1PR1 (0.44) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL2011716 | 0.78 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL14207981 | 0.78 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL14207629 | 0.78 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP3A4 | |
| SCHEMBL14208618 | 0.77 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964649-B2 | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-21 | — | — | US | disclosed |
| US-7964649-B2 | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-21 | — | — | US | disclosed |
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253760-A1 | HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885S1PR4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.