SCHEMBL20096773

SCHEMBL20096773

CC(C)(C)OC(=O)n1ccc2cc(Cl)c(Cl)cc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
PIK3CD O00329 2/20 0.42
ABL1 P00519 2/20 0.42
EGFR P00533 2/20 0.42
HCK P08631 2/20 0.42
SRC P12931 2/20 0.42
KDR P35968 2/20 0.42
PIK3CA P42336 2/20 0.42
PIK3CB P42338 2/20 0.42
MTOR P42345 2/20 0.42
PIK3CG P48736 2/20 0.42
EPHB4 P54760 2/20 0.42
PRKDC P78527 2/20 0.42
PI4KB Q9UBF8 2/20 0.42
BUB1 O43683 1/20 0.40
BCHE P06276 1/20 0.37
NR1H2 P55055 6/20 0.36
ACLY P53396 1/20 0.36
MEN1 O00255 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23709691 0.89 HSP90AA1 (0.41) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL21812352 0.89 HSP90AA1 (0.41) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL1037419 0.89 HSP90AA1 (0.41) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL12422259 0.88 SUV39H2 (0.42) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL1314628 0.86 HSP90AA1 (0.40) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL19476943 0.85 ATR (0.40) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL30071150 0.85 ATR (0.40) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL4387826 0.84 OXER1 (0.50) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL2006239 0.84 OXER1 (0.50) HSP90AA1HSP90AB1PIK3CDABL1EGFR
SCHEMBL29829168 0.84 OXER1 (0.50) HSP90AA1HSP90AB1PIK3CDABL1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12479807-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2025-11-25 US disclosed
US-20220235018-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2022-07-28 US disclosed
US-11345672-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2022-05-31 US disclosed
US-11345672-B2 Methods using HDAC11 inhibitors VALO HEALTH, INC. (US) 2022-05-31 US disclosed
US-20200079744-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2020-03-12 US disclosed
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2019-03-21 US disclosed
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS Valo Health, LLC 2019-03-21 US disclosed
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2019-03-21 US disclosed
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS VALO HEALTH, INC. 2019-03-21 US disclosed
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS VALO EARLY DISCOVERY, INC. 2018-05-10 US disclosed
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS VALO EARLY DISCOVERY, INC. 2018-05-10 US disclosed
WO-2018075959-A1 METHODS USING HDAC11 INHIBITORS FORMA THERAPEUTICS, INC. (US) 2018-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200079744-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-11345672-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-20180127386-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-12479807-B2 Methods using HDAC11 inhibitors HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-20190084945-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-20190084946-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885
US-20220235018-A1 METHODS USING HDAC11 INHIBITORS HDAC11, HDAC1, HDAC10 HSP90AA1 299/4885HSP90AB1 164/4885PIK3CD 3656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.