Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 7/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | MC3R | P41968 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | PTGFR | P43088 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18651347 | 0.87 | PDE4D (0.58) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL20097486 | 0.86 | PDE4D (0.54) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL19845845 | 0.84 | PDE4D (0.57) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL18656716 | 0.84 | PDE4D (0.66) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL19931412 | 0.82 | PDE4D (0.55) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL18651346 | 0.80 | PDE4D (0.56) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903056 | 0.80 | PDE4D (0.70) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903053 | 0.80 | PDE4D (0.70) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903915 | 0.80 | PDE4D (0.70) | PDE4DPGRADORA3ADRA2CSLC6A2 | |
| SCHEMBL8903910 | 0.80 | PDE4D (0.70) | PDE4DPGRADORA3ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956302-B2 | Compounds and compositions for the treatment of ocular disorders | Graybug Vision, Inc. (US) | 2018-05-01 | — | — | US | disclosed |