Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786600 | 0.80 | HSP90AB1 (0.57) | HSP90AB1HSP90AA1 | |
| SCHEMBL4785657 | 0.78 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1 | |
| SCHEMBL14777477 | 0.77 | HSP90AA1 (0.57) | HSP90AB1HSP90AA1 | |
| SCHEMBL14776846 | 0.75 | HSP90AA1 (0.47) | HSP90AB1HSP90AA1 | |
| SCHEMBL15522000 | 0.75 | HSP90AA1 (0.44) | HSP90AB1HSP90AA1 | |
| SCHEMBL15522103 | 0.75 | HSP90AA1 (0.43) | HSP90AB1HSP90AA1 | |
| SCHEMBL1304830 | 0.75 | HSP90AB1 (0.72) | HSP90AB1HSP90AA1 | |
| SCHEMBL28333629 | 0.74 | HSP90AA1 (0.51) | HSP90AB1HSP90AA1 | |
| SCHEMBL1865982 | 0.74 | HSP90AA1 (0.46) | HSP90AB1HSP90AA1 | |
| SCHEMBL1304891 | 0.74 | HSP90AB1 (0.54) | HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956293-B2 | Targeted therapeutics | MADRIGAL PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |