Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106407 | 0.93 | MDM2 (0.63) | MDM2 | |
| SCHEMBL20106113 | 0.85 | MDM2 (0.82) | MDM2 | |
| SCHEMBL20105795 | 0.85 | MDM2 (0.63) | MDM2 | |
| SCHEMBL20105791 | 0.85 | MDM2 (0.63) | MDM2 | |
| SCHEMBL20106264 | 0.85 | MDM2 (0.83) | MDM2 | |
| SCHEMBL20106406 | 0.85 | MDM2 (0.53) | MDM2 | |
| SCHEMBL20105679 | 0.84 | MDM2 (0.65) | MDM2 | |
| SCHEMBL20106494 | 0.84 | MDM2 (0.66) | MDM2 | |
| SCHEMBL20105682 | 0.84 | MDM2 (0.65) | MDM2 | |
| SCHEMBL20106181 | 0.83 | MDM2 (0.74) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |