Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17314544 | 0.88 | KDM4E (0.40) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL17314542 | 0.88 | KDM4E (0.40) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL18256682 | 0.76 | KDM4E (0.33) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL17682245 | 0.73 | EPHX2 (0.44) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL19036786 | 0.73 | KDM4E (0.52) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL15075767 | 0.72 | KDM4E (0.46) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL15075874 | 0.72 | MEN1 (0.47) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL15075764 | 0.71 | KDM4E (0.44) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL9412532 | 0.70 | KDM4E (0.51) | EPHX2KDM4EALDH1A1GAAKMT2A | |
| SCHEMBL19036641 | 0.70 | KDM4E (0.50) | EPHX2KDM4EALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |