Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106102 | 0.94 | MDM2 (0.63) | MDM2TP53 | |
| SCHEMBL20106063 | 0.94 | MDM2 (0.63) | MDM2TP53 | |
| SCHEMBL20106369 | 0.92 | MDM2 (0.56) | MDM2 | |
| SCHEMBL20105719 | 0.91 | MDM2 (0.57) | MDM2 | |
| SCHEMBL20105802 | 0.89 | MDM2 (0.57) | MDM2 | |
| SCHEMBL20106130 | 0.89 | MDM2 (0.57) | MDM2 | |
| SCHEMBL20106255 | 0.88 | MDM2 (0.64) | MDM2TP53 | |
| SCHEMBL20106395 | 0.88 | MDM2 (0.56) | MDM2 | |
| SCHEMBL20105785 | 0.87 | MDM2 (0.58) | MDM2 | |
| SCHEMBL20106165 | 0.86 | MDM2 (0.55) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |